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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5438 | PROTAC CDK9 Degrader-1 | CDK | |
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader. | |||
T74707 | PROTAC FLT3/CDK9 degrader-1 | ||
PROTAC FLT3/CDK9 degrader-1, a potent dual degrader of FLT3 and CDK9, effectively induces apoptosis and targets protein degradation of FLT3 and CDK9. This compound holds research potential for FLT3-ITD mutated AML [1]. | |||
T10743 | CDK9-IN-11 | CDK | |
CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1]. | |||
T79904 | PROTAC CDK9/CycT1 Degrader-2 | CDK | |
PROTAC CDK9/CycT1 Degrader-2 inhibits CDK9 with an IC50 of 45 nM [1]. | |||
T74853 | PROTAC CDK9 degrader-7 | ||
PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (CDK9) through the proteasome pathway [1]. | |||
T78928 | PROTAC CDK9 degrader-8 | PROTACs | |
PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1]. | |||
T74851 | PROTAC CDK9 degrader-5 | PROTACs | |
PROTAC CDK9 degrader-5 is a selective PROTAC that mediates degradation of CDK9 via the proteasome pathway. It efficiently degrades the CDK9 42 and CDK9 55 isoforms with DC50 values of 0.10 μM and 0.14 μM, respectively [1... | |||
T17728 | PROTAC CDK9 degrader-2 | Others | |
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to... | |||
T12552 | PROTAC CDK2/9 Degrader-1 | CDK | |
PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM). | |||
T74852 | PROTAC CDK9 degrader-6 | CDK | |
PROTAC CDK9 degrader-6 is a specific PROTAC targeting CDK9 that mediates its degradation through the proteasome pathway. This compound effectively degrades CDK9 with DC50 values of 0.10 μM and 0.14 μM for the CDK9 42 and... | |||
T36744 | CDK9 Antagonist-1 | CDK9 Antagonist-1 | |
CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form... | |||
T79704 | CDK9-IN-28 | CDK | |
PROTAC CDK9/CycT1 Degrader-1 (compounds 10), a potent CDK9 inhibitor, serves as a target protein ligand for PROTAC synthesis. Exhibiting substantial anti-proliferative activity in solid tumors [1], this compound is instr... | |||
T78837 | CP-07 | CDK | |
CP-07 is a selective and effective PROTAC CDK9 degrader (DC50: 43 nM), demonstrating inhibition of 22RV1 cell proliferation (IC50: 62 nM) and colony formation by attenuating levels of Mcl-1 and c-Myc. Additionally, CP-07... |